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Wnt signaling in ankylosing spondylitis

Authors
  • Corr, Maripat
Type
Published Article
Journal
Clinical Rheumatology
Publisher
Springer-Verlag
Publication Date
May 13, 2014
Volume
33
Issue
6
Pages
759–762
Identifiers
DOI: 10.1007/s10067-014-2663-6
Source
Springer Nature
Keywords
License
Yellow

Abstract

The mechanisms that lead to bony fusion in ankylosing spondylitis (AS) are yet to be fully defined. In recent years, there have been several advances in our understanding of this complex disease. Here, the potential impact of the Wnt signaling pathway will be discussed. This pathway is involved in bone morphogenesis and homeostasis. Perturbations in the normal regulation have been implicated in abnormal bone formation (e.g., osteophytes). Levels of Wnt regulatory proteins like Dickkopf have been investigated as potential biomarkers of disease. This pathway might be involved in other aspects of this disease including T cell activation and differentiation, and in bone marrow adipogenesis. The pathways leading to the unique pathology and bony fusion in AS are complex and the Wnt pathway might play a critical contributing role.

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