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WITHDRAWN: Antibiotics for exacerbations of chronic obstructive pulmonary disease.

Authors
  • Ram, Felix Sf
  • Rodriguez-Roisin, Robert
  • Granados-Navarrete, Alicia
  • Garcia-Aymerich, Judith
  • Barnes, Neil C
Type
Published Article
Journal
The Cochrane database of systematic reviews
Publication Date
Jan 01, 2011
Issue
1
Identifiers
DOI: 10.1002/14651858.CD004403.pub3
PMID: 21249661
Source
Medline
License
Unknown

Abstract

This review shows that in COPD exacerbations with increased cough and sputum purulence antibiotics, regardless of choice, reduce the risk of short-term mortality by 77%, decrease the risk of treatment failure by 53% and the risk of sputum purulence by 44%; with a small increase in the risk of diarrhoea. These results should be interpreted with caution due to the differences in patient selection, antibiotic choice, small number of included trials and lack of control for interventions that influence outcome, such as use of systemic corticosteroids and ventilatory support. Nevertheless, this review supports antibiotics for patients with COPD exacerbations with increased cough and sputum purulence who are moderately or severely ill.

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