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Withaferin A : from ayurvedic folk medicine to preclinical anti-cancer drug

Authors
  • Hassannia, Behrouz
  • Logie, Emilie
  • Vandenabeele, Peter
  • Vanden Berghe, Tom
  • Vanden Berghe, Wim
Publication Date
Jan 01, 2020
Identifiers
DOI: 10.1016/j.bcp.2019.08.004
OAI: oai:archive.ugent.be:8650593
Source
Ghent University Institutional Archive
Keywords
Language
English
License
Unknown
External links

Abstract

Despite the recent successes of targeted cancer immuno-therapies, drug resistance and disease relapse remain a huge burden in cancer patient treatment. This has fueled renewed interest in natural product discovery to identify new pharmacophores for innovative cancer drug development. Reverse pharmacology approaches of Withania somnifera leaves and roots (alternatively also called Ashwagandha or Indian ginseng in traditional Ayurvedic and Unani folk medicine) have identified Withaferin A (WA) as the most bioactive compound for treatment of inflammatory ailments, supporting traditional use of their corresponding extracts in indigenous medicine. In this review we summarize preclinical in vivo evidence for therapeutic cancer applications of WA and provide a biochemical framework of its polypharmaceutical effects against cancer hallmarks.

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