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Why do adipocytes make the beta 3 adrenergic receptor?

Authors
  • Granneman, J G
Type
Published Article
Journal
Cellular Signalling
Publisher
Elsevier
Publication Date
Jan 01, 1995
Volume
7
Issue
1
Pages
9–15
Identifiers
PMID: 7756115
Source
Medline
License
Unknown

Abstract

Adipocytes express a mixture of beta-adrenergic receptor subtypes, including the recently characterized beta 3 receptor. The co-expression of these subtypes by fat cells suggest they serve different signalling functions. In this review, the properties of recombinant and natively-expressed beta 3 receptors are detailed and contrasted with those of beta 1 and beta 2 receptors. The beta 3 receptor appears to differ from the other beta receptor subtypes with respect to receptor coupling efficiency, G-protein coupling specificity and regulation by agonist exposure. Lastly, the potential of the beta 3 receptor as a therapeutic target is discussed in view of new data regarding its tissue distribution in humans.

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