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Whole-Exome Sequencing to Identify Novel Biological Pathways Associated With Infertility After Pelvic Inflammatory Disease.

Authors
  • Taylor, Brandie D1
  • Zheng, Xiaojing
  • Darville, Toni
  • Zhong, Wujuan
  • Konganti, Kranti
  • Abiodun-Ojo, Olayinka
  • Ness, Roberta B
  • O'Connell, Catherine M
  • Haggerty, Catherine L
  • 1 From the *Department of Epidemiology and Biostatistics, Texas A&M University, College Station, TX; †Department of Pediatrics, ‡Department of Biostatistics, University of North Carolina Chapel Hill, Chapel Hill, NC; §Institute for Genome Sciences and Society, Texas A&M University, College Station, TX; ¶University of Texas School of Public Health, Houston, TX; and ∥Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA.
Type
Published Article
Journal
Sexually transmitted diseases
Publication Date
Jan 01, 2017
Volume
44
Issue
1
Pages
35–41
Identifiers
PMID: 27898568
Source
Medline
License
Unknown

Abstract

Focus genes were enriched in pathways that impact innate and adaptive immunity, protein kinase A activity, cellular growth, and DNA repair. These may alter host resistance or immunopathology after infection. Targeted sequencing of biological pathways identified in this study may provide insight into STI-related infertility.

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