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Whole gene analysis of a genotype G29P[6] human rotavirus strain identified in Central African Republic

Authors
  • Banga-Mingo, Virginie1
  • Esona, Mathew D.2
  • Betrapally, Naga S.2
  • Gautam, Rashi2
  • Jaimes, Jose2
  • Katz, Eric2
  • Waku-Kouomou, Diane2
  • Bowen, Michael D.2
  • Gouandjika-Vasilache, Ionela1
  • 1 Institut Pasteur de Bangui, Ave de L’Indépendance, Bangui, Central African Republic , Bangui (Central African Republic)
  • 2 NCIRD, CDC, 1600 Clifton Road, NE, Atlanta, GA, 30329, USA , Atlanta (United States)
Type
Published Article
Journal
BMC Research Notes
Publisher
Springer (Biomed Central Ltd.)
Publication Date
May 31, 2021
Volume
14
Issue
1
Identifiers
DOI: 10.1186/s13104-021-05634-4
Source
Springer Nature
Keywords
License
Green

Abstract

ObjectiveRotavirus A (RVA) remains the main causative agent of gastroenteritis in young children and the young of many mammalian and avian species. In this study we describe a RVA strain detected from a 6-month-old child from Central African Republic (CAR).ResultsWe report the 11 open reading frame sequences of a G29-P[6]-I2-R2-C2-M2-A2-N2-T2-E2-H2 rotavirus strain, RVA/Human-wt/CAR/CAR91/2014/G29P[6]. Nine genes (VP1–VP3, VP6, NSP1–NSP5) shared 90–100% sequence similarities with genogroup 2 rotaviruses. Phylogenetically, backbone genes, except for VP3 and NSP4 genes, were linked with cognate gene sequences of human DS-1-like genogroup 2, hence their genetic origin. The VP3 and NSP4 genes, clustered genetically with both human and animal strains, an indication genetic reassortment human and animal RVA strains has taken place. The VP7 gene shared nucleotide (93–94%) and amino acid (95.5–96.7%) identities with Kenyan and Belgian human G29 strains, as well as to buffalo G29 strain from South Africa, while the VP4 gene most closely resembled P[6]-lineage I strains from Africa and Bangladesh (97%).

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