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Whole cells in enantioselective reduction of benzyl acetoacetate.

Authors
  • Ribeiro, Joyce Benzaquem
  • Ramos, Aline de Souza
  • Lopes, Raquel de Oliveira
  • da Silva, Gabriela Veloso Vieira
  • de Souza, Rodrigo Octavio Mendonça Alves...
Type
Published Article
Journal
Brazilian Journal of Microbiology
Publisher
Elsevier
Publication Date
Jan 01, 2014
Volume
45
Issue
3
Pages
929–932
Identifiers
PMID: 25477927
Source
Medline
Keywords
License
Unknown

Abstract

The β-ketoester benzyl acetoacetate was enantioselectively reduced to benzyl (S)-3-hydroxybutanoate by seven microorganism species. The best result using free cells was obtained with the yeast Hansenula sp., which furnished 97% ee and 85% of conversion within 24 h. After immobilization in calcium alginate spheres, K.marxianus showed to be more stable after 2 cycles of reaction.

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