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Impact of Depression and Anxiety on Dimensions of Health-Related Quality of Life in Subjects with Parkinson's Disease Enrolled in an Association of Patients.

Authors
  • Chuquilín-Arista, Fany1, 2
  • Álvarez-Avellón, Tania3
  • Menéndez-González, Manuel4, 5, 6
  • 1 Community and Family Medicine, Health Area VII-Asturias, Plaza de los Sindicatos Mineros 3, 33600 Mieres, Spain. , (Spain)
  • 2 Health Science Research, Doctoral School, University of Valladolid, Calle Real de Burgos s/n, 47011 Valladolid, Spain. , (Spain)
  • 3 Department of Psychology, Universidad de Oviedo, Plaza Feijoo s/n, 33003 Oviedo, Spain. , (Spain)
  • 4 Department of Neurology, Hospital Universitario Central de Asturias (HUCA), Avenida Roma s/n, 33011 Oviedo, Spain. , (Spain)
  • 5 Instituto de Salud del Principado de Asturias (ISPA), Avenida del Hospital Universitario s/n, 33011 Oviedo, Spain. , (Spain)
  • 6 Department of Medicine, Universidad de Oviedo, Calle Julián Clavería 6, 33006 Oviedo, Spain. , (Spain)
Type
Published Article
Journal
Brain Sciences
Publisher
MDPI AG
Publication Date
Jun 10, 2021
Volume
11
Issue
6
Identifiers
DOI: 10.3390/brainsci11060771
PMID: 34200659
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Parkinson's disease (PD) is a complex disorder characterized by a wide spectrum of symptoms. Depression and anxiety are common manifestations in PD and may be determinants of health-related quality of life (HRQoL). The objective of this study is to determine the association of depression and anxiety with the dimensions of HRQoL in subjects with PD enrolled in an association of patients. Ninety-five community-based patients with PD diagnosis at different disease stages were studied. HRQoL was assessed using the Parkinson's Disease Questionnaire (PDQ-39); depression and anxiety were assessed using the Beck Depression Inventory (BDI-II) and the State-Trait Anxiety Inventory (STAI), respectively. Our results showed that depression and anxiety were negatively associated with HRQoL measured by PDSI. Higher motor dysfunction measured by Hoehn and Yahr (H&Y) staging was also associated with worse HRQoL. Depression was the most influential variable in the model. All PDQ-39 dimensions except social support and bodily discomfort were associated with depression. Anxiety was associated with the emotional well-being and bodily discomfort dimensions. These results suggest that physicians should pay attention to the presence of psychiatric symptoms and treat them appropriately.

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