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Whole Body Vibration Training on Muscle Strength and Brain-Derived Neurotrophic Factor Levels in Elderly Woman With Knee Osteoarthritis: A Randomized Clinical Trial Study.

Authors
  • Simão, Adriano Prado1
  • Mendonça, Vanessa Amaral2, 3, 4
  • Avelar, Núbia Carelli Pereira5
  • da Fonseca, Sueli Ferreira2, 3
  • Santos, Jousielle Márcia2, 3
  • de Oliveira, Ana Carolina Coelho2, 4
  • Tossige-Gomes, Rosalina2, 3
  • Ribeiro, Vanessa Gonçalves César2, 3
  • Neves, Camila Danielle Cunha2, 3
  • Balthazar, Cláudio Heitor2, 3
  • Leite, Hércules Ribeiro2, 3, 4
  • Figueiredo, Pedro Henrique Scheidt2, 3, 4
  • Bernardo-Filho, Mário6
  • Lacerda, Ana Cristina Rodrigues2, 3, 4
  • 1 Departamento de Fisioterapia, Universidade Federal de Alfenas (UNIFAL), Alfenas, Brazil. , (Brazil)
  • 2 Centro Integrado de Pós-Graduação e Pesquisa em Saúde (CIPq-Saúde), Universidade Federal dos Vales do Jequitinhonha e Mucuri (UFVJM), Diamantina, Brazil. , (Brazil)
  • 3 Programa Multicêntrico de Pós-Graduação em Ciências Fisiológicas (PMPGCF), Sociedade Brasileira de Fisiologia (SBFis), Butanta, Brazil. , (Brazil)
  • 4 Programa de Pós-Graduação em Reabilitação e Desempenho Funcional (PPGReab), Universidade Federal dos Vales do Jequitinhonha e Mucuri (UFVJM), Diamantina, Brazil. , (Brazil)
  • 5 Departamento de Ciências da Saúde, Universidade Federal de Santa Catarina (UFSC), Araranguá, Brazil. , (Brazil)
  • 6 Departamento de Biofísica e Biometria, Instituto de Biologia Roberto Alcântara Gomes, Universidade Federal do Estado do Rio de Janeiro, Rio de Janeiro, Brazil. , (Brazil)
Type
Published Article
Journal
Frontiers in Physiology
Publisher
Frontiers Media SA
Publication Date
Jan 01, 2019
Volume
10
Pages
756–756
Identifiers
DOI: 10.3389/fphys.2019.00756
PMID: 31293437
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Background: Osteoarthritis of the knee (kOA) is a chronic, progressive, degenerative health condition that contributes to the imbalance between the synthesis and destruction of articular cartilage. Recently, whole body vibration (WBV) training has been recommended as an effective alternative for strength training in elderly people, and various physiological effects are obtained in response to exercise performed on a vibratory platform, such as an increase in muscle activation and improved muscle performance. However, the effects of WBV particularly on the strength of the quadriceps muscle and neuronal plasticity are unknown. Objective: The aim of this study was to evaluate the effects of adding WBV to squat training on the isometric quadriceps muscle strength (IQMS) and the plasma levels of brain-derived neurotrophic factor (BDNF) in elderly woman with kOA. Methods: Fifteen elderly women ≥65 years of age with kOA were randomized into two interventions: (1) the vibration group (VG), in which participants performed squat exercise training in association with WBV or (2) the exercise group (EG), in which participants performed squat exercise training without vibration, for 12 weeks 3×/week. Results: Compared to the EG group, the VG group demonstrated a significantly greater delta (Δ) in IQMS values (IC95% 0.43-7.06; p ≤ 0.05) and in Δ BDNF plasma levels (IC95% -32.51 to 4.217; p ≤ 0.05) after the intervention period. There was an association between increase of Δ BDNF plasma levels and increase of Δ IQMS (β = 0.57; R 2 = 0.32; p = 0.03). Conclusion: The addition of WBV to squat exercise training improves lower limb muscle performance in elderly women with kOA. These findings suggest that the improvement in muscle performance is related to neuromuscular adaptations induced by WBV. Clinical Trial Registration: www.ClinicalTrials.gov, identifier NCT03918291.

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