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Whole blood microRNA expression pattern differentiates patients with rheumatoid arthritis, their seropositive first-degree relatives, and healthy unrelated control subjects.

Authors
  • Anaparti, Vidyanand1, 2, 3
  • Smolik, Irene1, 3, 4
  • Meng, Xiaobo1, 2, 3
  • Spicer, Victor2
  • Mookherjee, Neeloffer1, 2, 5
  • El-Gabalawy, Hani6, 7, 8, 9, 10
  • 1 Department of Internal Medicine, Rady Faculty of Health Sciences, University of Manitoba, Room 799, 715 McDermot Avenue, Winnipeg, MB, R3E 3P4, Canada. , (Canada)
  • 2 Manitoba Centre for Proteomics and Systems Biology, University of Manitoba, Winnipeg, MB, Canada. , (Canada)
  • 3 Rheumatic Diseases Unit, University of Manitoba, Winnipeg, MB, Canada. , (Canada)
  • 4 Division of Rheumatology, Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada. , (Canada)
  • 5 Department of Immunology, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada. , (Canada)
  • 6 Department of Internal Medicine, Rady Faculty of Health Sciences, University of Manitoba, Room 799, 715 McDermot Avenue, Winnipeg, MB, R3E 3P4, Canada. [email protected] , (Canada)
  • 7 Manitoba Centre for Proteomics and Systems Biology, University of Manitoba, Winnipeg, MB, Canada. [email protected] , (Canada)
  • 8 Rheumatic Diseases Unit, University of Manitoba, Winnipeg, MB, Canada. [email protected] , (Canada)
  • 9 Division of Rheumatology, Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada. [email protected] , (Canada)
  • 10 Department of Immunology, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada. [email protected] , (Canada)
Type
Published Article
Journal
Arthritis research & therapy
Publication Date
Nov 10, 2017
Volume
19
Issue
1
Pages
249–249
Identifiers
DOI: 10.1186/s13075-017-1459-x
PMID: 29126434
Source
Medline
Keywords
License
Unknown

Abstract

We highlight systematically altered circulating miRNA expression in at-risk FDRs prior to RA onset, a profile they shared with patients with RA. Prominently consistent miR-103a-3p expression indicates its utility as a prognostic biomarker for preclinical RA while highlighting biological pathways important for transition to clinically detectable disease.

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