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Who develops severe or fatal adverse drug reactions to selective serotonin reuptake inhibitors?

Authors
Type
Published Article
Journal
Canadian journal of psychiatry. Revue canadienne de psychiatrie
Publication Date
Volume
46
Issue
3
Pages
258–263
Identifiers
PMID: 11320680
Source
Medline

Abstract

SSRIs are relatively safe when their widespread use is compared with the prevalence of ADRs. SSRIs may, however, be associated with ADRs, and even death, following intentional overdose or when taken with 2 or more other drugs or alcohol (particularly another drug metabolized by CYP-450). Physicians prescribing SSRIs need to consider drug-drug interactions and carefully monitor patients with severe affective disorders, comorbid medical conditions (especially cardiovascular disease), alcohol abuse, or a history of overdosing.

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