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White matter lesions detected by magnetic resonance imaging after radiotherapy and high-dose chemotherapy in children with medulloblastoma or primitive neuroectodermal tumor.

Authors
  • Fouladi, Maryam
  • Chintagumpala, Murali
  • Laningham, Fred H
  • Ashley, David
  • Kellie, Stewart J
  • Langston, James W
  • McCluggage, Charles W
  • Woo, Shaio
  • Kocak, Mehmet
  • Krull, Kevin
  • Kun, Larry E
  • Mulhern, Raymond K
  • Gajjar, Amar
Type
Published Article
Journal
Journal of clinical oncology : official journal of the American Society of Clinical Oncology
Publication Date
Nov 15, 2004
Volume
22
Issue
22
Pages
4551–4560
Identifiers
PMID: 15542806
Source
Medline
License
Unknown

Abstract

WMLs in medulloblastoma or PNET patients treated with conformal radiotherapy and HDC are typically transient and asymptomatic, and may mimic early tumor recurrence. A minority of patients with WMLs develop permanent neurologic deficits and imaging changes. Overall, the presence of WMLs is associated with greater neurocognitive decline.

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