Affordable Access

Access to the full text

White Matter Integrity and Episodic Memory Performance in Mild Cognitive Impairment: A Diffusion Tensor Imaging Study

Authors
  • Goldstein, Felicia C.1, 2
  • Mao, Hui3
  • Wang, Liya3, 4
  • Ni, Chunchun3
  • Lah, James J.1
  • Levey, Allan I.1
  • 1 Emory University School of Medicine, Department of Neurology, Atlanta, GA, USA , Atlanta (United States)
  • 2 Wesley Woods Health Center, Neurology Department, 1841 Clifton Road, N.E., Atlanta, GA, 30329, USA , Atlanta (United States)
  • 3 Emory University School of Medicine, Department of Radiology, Atlanta, GA, USA , Atlanta (United States)
  • 4 The Second Hospital of Shenzhen, Department of Radiology, Shenzhen, Guangdong, 518038, China , Shenzhen (China)
Type
Published Article
Journal
Brain Imaging and Behavior
Publisher
Springer-Verlag
Publication Date
Jan 09, 2009
Volume
3
Issue
2
Pages
132–141
Identifiers
DOI: 10.1007/s11682-008-9055-y
Source
Springer Nature
Keywords
License
Yellow

Abstract

White matter (WM) integrity in the medial temporal lobes and episodic memory performance were examined in patients with mild cognitive impairment (MCI) and age-matched cognitively intact controls. Material specific associations between WM in the left versus right hemisphere and verbal versus visual memory performance were examined as well. Fourteen right-handed amnestic MCI patients underwent diffusion tensor imaging (DTI) and received verbal (words, story) and visual (designs) memory tests. Delayed verbal memory was significantly correlated with loss of WM integrity in the medial temporal lobe. This finding was associated with both the left and right temporal regions. Immediate visual memory performance was significantly correlated with the loss of WM integrity in the left temporal region. The results indicate that WM integrity in the medial temporal lobe is associated with objective memory functioning in MCI. However, strong material specific relationships were not observed, possibly reflecting diverse encoding strategies used by participants such as imagery of verbal material and verbal encoding of designs.

Report this publication

Statistics

Seen <100 times