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The white matter architecture underlying semantic processing: A systematic review.

Authors
  • Cocquyt, E-M1
  • Lanckmans, E2
  • van Mierlo, P3
  • Duyck, W4
  • Szmalec, A5
  • Santens, P6
  • De Letter, M2
  • 1 Department of Rehabilitation Sciences, Ghent University, Belgium; Research Group BrainComm, Ghent University, Belgium. Electronic address: [email protected] , (Belgium)
  • 2 Department of Rehabilitation Sciences, Ghent University, Belgium; Research Group BrainComm, Ghent University, Belgium. , (Belgium)
  • 3 Research Group BrainComm, Ghent University, Belgium; Department of Electronics and Information Systems, Medical Image and Signal Processing Group, Ghent University, Belgium. , (Belgium)
  • 4 Faculty of Psychology and Educational Sciences, Department of Experimental Psychology, Ghent University, Belgium. , (Belgium)
  • 5 Faculty of Psychology and Educational Sciences, Department of Experimental Psychology, Ghent University, Belgium; Psychological Sciences Research Institute, Université catholique de Louvain, Louvain-la-Neuve, Belgium. , (Belgium)
  • 6 Research Group BrainComm, Ghent University, Belgium; Department of Neurology, Ghent University Hospital, Belgium. , (Belgium)
Type
Published Article
Journal
Neuropsychologia
Publication Date
Sep 27, 2019
Volume
136
Pages
107182–107182
Identifiers
DOI: 10.1016/j.neuropsychologia.2019.107182
PMID: 31568774
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

From a holistic point of view, semantic processes are subserved by large-scale subcortico-cortical networks. The dynamic routing of information between grey matter structures depends on the integrity of subcortical white matter pathways. Nonetheless, controversy remains on which of these pathways support semantic processing. Therefore, a systematic review of the literature was performed with a focus on anatomo-functional correlations obtained from direct electrostimulation during awake tumor surgery, and conducted between diffusion tensor imaging metrics and behavioral semantic performance in healthy and aphasic individuals. The 43 included studies suggest that the left inferior fronto-occipital fasciculus contributes to the essential connectivity that allows semantic processing. However, it remains uncertain whether its contributive role is limited to the organization of semantic knowledge or extends to the level of semantic control. Moreover, the functionality of the left uncinate fasciculus, inferior longitudinal fasciculus and the posterior segment of the indirect arcuate fasciculus in semantic processing has to be confirmed by future research. Copyright © 2019 Elsevier Ltd. All rights reserved.

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