What is a T-cell clone? Effect of rIFN on T-cell clone function and T-cell receptor gene rearrangement.
- Published Article
- Publication Date
Nov 01, 1986
A T4+ proliferative, noncytotoxic cloned line acquires specific lytic function by treatment with recombinant interferon alpha or gamma. Simultaneous with the acquisition of this new cell function, a rearrangement of the T-cell receptor alpha gene occurs. These changes necessitate a revised concept of a T-cell clone regarding its T-cell receptor gene configuration and cell function.
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The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/2432042