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What is a T-cell clone? Effect of rIFN on T-cell clone function and T-cell receptor gene rearrangement.

Authors
Type
Published Article
Journal
Human Immunology
0198-8859
Publisher
Elsevier
Publication Date
Volume
17
Issue
3
Pages
214–223
Identifiers
PMID: 2432042
Source
Medline
License
Unknown

Abstract

A T4+ proliferative, noncytotoxic cloned line acquires specific lytic function by treatment with recombinant interferon alpha or gamma. Simultaneous with the acquisition of this new cell function, a rearrangement of the T-cell receptor alpha gene occurs. These changes necessitate a revised concept of a T-cell clone regarding its T-cell receptor gene configuration and cell function.

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