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What Is the Role of the Inflammation in the Pathogenesis of Heart Failure?

Authors
  • Castillo, Elena C.1
  • Vázquez-Garza, Eduardo1
  • Yee-Trejo, David1
  • García-Rivas, Gerardo1, 2, 3
  • Torre-Amione, Guillermo1, 2, 4
  • 1 Escuela de Medicina y Ciencias de la Salud, Ave. Morones Prieto 3000, Monterrey, NL, 64710, Mexico , Monterrey (Mexico)
  • 2 Hospital Zambrano Hellion, TecSalud, San Pedro Garza García, NL, 66278, Mexico , San Pedro Garza García (Mexico)
  • 3 Hospital Zambrano Hellion, TecSalud, San Pedro Garzar García, NL, 66278, Mexico , San Pedro Garzar García (Mexico)
  • 4 Cornell University, Houston, TX, USA , Houston (United States)
Type
Published Article
Journal
Current Cardiology Reports
Publisher
Springer-Verlag
Publication Date
Sep 10, 2020
Volume
22
Issue
11
Identifiers
DOI: 10.1007/s11886-020-01382-2
Source
Springer Nature
Keywords
License
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Abstract

Purpose of ReviewIn heart failure, whether it is associated with reduced or preserved ejection fraction, the immune system is activated and contributes to heart remodeling and impaired function.Recent FindingsStudies indicate that cells of the immune system not only play a role in the pathology but are also critical regulators of heart function. Knowledge about the role of the immune system driving heart failure will lead to the development of new targets to this system, particularly in those patients that, despite the apparent wellness, relapse and worsen.SummaryIn this review, we will address the diverse mechanisms that trigger inflammation and their impact on heart failure progression.

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