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What role does mitochondrial stress play in neurodegenerative diseases?

Authors
  • Pickrell, Alicia Mae
  • Moraes, Carlos Torres
Type
Published Article
Journal
Methods in Molecular Biology
Publication Date
Jan 01, 2010
Volume
648
Pages
63–78
Identifiers
DOI: 10.1007/978-1-60761-756-3_4
PMID: 20700705
Source
Medline
License
Unknown

Abstract

The essential need for mitochondrial function has been extensively shown to relate to neuronal health. Neurodegeneration and neurodegeneration-related diseases have been associated with multiple mitochondrial dysfunctions. This review highlights key findings related to commonly studied mitochondrial dysfunctions: imbalance of mitochondrial dynamics, mutations in the mitochondrial genome, excessive reactive oxygen species, and misfolded protein associations/interactions with the mitochondria. Future research in mitochondrial function will help elucidate complex neurodegenerative events while impacting both individual and societal health.

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