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What does the susceptible-dose dependent interpretive category for cefepime in ESBL-producing bacteria?

Authors
  • Menegucci, Thatiany Cevallos1
  • Bastos, Marina de Souza1
  • Viana, Giselle Fukita1
  • Moreira, Rafael Renato Brondani1
  • Garcia, Lourdes Botelho1
  • Cardoso, Celso Luiz1
  • Tognim, Maria Cristina Bronharo1
  • 1 a Departamento de Ciências Básicas da Saúde , Universidade Estadual de Maringá , Maringá , Brazil. , (Brazil)
Type
Published Article
Journal
Journal of chemotherapy (Florence, Italy)
Publication Date
Jun 01, 2017
Volume
29
Issue
3
Pages
189–194
Identifiers
DOI: 10.1080/1120009X.2015.1120407
PMID: 27077929
Source
Medline
Keywords
License
Unknown

Abstract

In this study, we investigated the frequency of isolates included in the susceptible-dose dependent (SDD) category, according to the Clinical and Laboratory Standards Institute guidelines, carrying blaTEM, blaSHV and blaCTX genes among 92 Klebsiella pneumoniae and 80 Enterobacter cloacae clinical isolates. The presence of one or more extended-spectrum β-lactamases (ESBLs) genes was observed in 64% K. pneumoniae and 69% E. cloacae isolates. Nineteen isolates were included in SDD interpretive category criteria, of which 15 carried ESBL genes (seven K. pneumoniae and eight E. cloacae). Considering the high proportion of ESBL gene-containing isolates included in the SDD category (79%), we recommend that physicians exercise caution in the use of cefepime for treatment of infections caused by these isolates, reducing possible therapeutic failure, particularly in cases of ESBL-producing bacterial strains.

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