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What do we know about the mechanisms of aromatase inhibitor resistance?

Authors
  • Shiuan Chen
  • Selma Masri
  • Xin Wang
  • Sheryl Phung
  • Yate-Ching Yuan
  • Xiwei Wu
Publication Date
Oct 19, 2006
Source
PMC
Keywords
Disciplines
  • Biology
  • Medicine
License
Unknown

Abstract

Clinical trials have demonstrated the importance of aromatase inhibitor (AI) therapy in the effective treatment of hormone-dependent breast cancers. Yet, as with all prolonged drug therapy, resistance to aromatase inhibitors does develop. To date, the precise mechanism responsible for resistance to aromatase inhibitors is not completely understood. In this paper, several mechanisms of de novo/intrinsic resistance and acquired resistance to AIs are discussed. These mechanisms are hypothesized based on important findings from a number of laboratories.

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