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Wet spinning of a library of carbohydrate low molecular weight gels

Authors
  • Bordignon, Delphine
  • Lonetti, Barbara
  • Coudret, Christophe
  • Roblin, Pierre
  • Joseph, Pierre
  • Malaquin, Laurent
  • Chalard, Anaïs
  • Fitremann, Juliette
Publication Date
Dec 01, 2021
Identifiers
DOI: 10.1016/j.jcis.2021.06.058
OAI: oai:HAL:hal-03278411v1
Source
HAL
Keywords
Language
English
License
Unknown
External links

Abstract

Hypothesis Recently, a low molecular weight hydrogel based on a carbohydrate alkyl amide has been successfully used as biomaterial for neuron cell culture and for 3D printing. Varying the molecular structure should make it possible to extend the library of carbohydrate low molecular weight hydrogels available for these applications and to improve their performances. Experiments Thirteen molecules easy to synthetize and designed to be potentially biocompatible were prepared. They are based on gluconamide, glucoheptonamide, galactonamide, glucamide, aliphatic chains and glycine. Their gelation in water was investigated in thermal conditions and wet spinning conditions, namely by dimethylsulfoxide-water exchange under injection. Findings Nine molecules give hydrogels in thermal conditions. By wet spinning, six molecules selfassemble fast enough, within few seconds, to form continous hydrogel filaments. Therefore, the method enables to shape by injection these mechanically fragile hydrogels, notably in the perspective of 3D printing. Depending on the molecular structure, persistent or soluble gel filaments are obtained. The microstructures are varied, featuring entangled ribbons, platelets or particles. In thermal gelation, molecules with a symmetrical polar head (galacto, glucoheptono) give flat ribbons and molecules with an asymmetrical polar head (gluco) give helical ribbons. The introduction of an extra glycine linker disturbs this trend.

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