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Weighting and standardization of frequencies to determine prevalence of AD imaging biomarkers.

Authors
  • Roberts, Rosebud O1
  • Knopman, David S2
  • Syrjanen, Jeremy A2
  • Aakre, Jeremiah A2
  • Vassilaki, Maria2
  • Kremers, Walter K2
  • Mielke, Michelle M2
  • Machulda, Mary M2
  • Graff-Radford, Jonathan2
  • Geda, Yonas E2
  • Vemuri, Prashanthi2
  • Lowe, Val2
  • Jack, Clifford R Jr2
  • Petersen, Ronald C2
  • 1 From the Divisions of Epidemiology (R.O.R., M.V., M.M. Mielke, R.C.P.) and Biomedical Statistics and Informatics (J.A.S., J.A.A., W.K.K.), Department of Health Sciences Research, Department of Neurology (R.O.R., D.S.K., M.M. Mielke, J.G.-R., R.C.P.), Department of Psychiatry and Psychology (M.M. Machulda), and Department of Radiology (P.V., V.L., C.R.J.), Mayo Clinic, Rochester, MN; and Departments of Psychiatry and Psychology and Neurology (Y.E.G.), Mayo Clinic, Scottsdale, AZ. [email protected]
  • 2 From the Divisions of Epidemiology (R.O.R., M.V., M.M. Mielke, R.C.P.) and Biomedical Statistics and Informatics (J.A.S., J.A.A., W.K.K.), Department of Health Sciences Research, Department of Neurology (R.O.R., D.S.K., M.M. Mielke, J.G.-R., R.C.P.), Department of Psychiatry and Psychology (M.M. Machulda), and Department of Radiology (P.V., V.L., C.R.J.), Mayo Clinic, Rochester, MN; and Departments of Psychiatry and Psychology and Neurology (Y.E.G.), Mayo Clinic, Scottsdale, AZ.
Type
Published Article
Journal
Neurology
Publisher
Ovid Technologies (Wolters Kluwer) - American Academy of Neurology
Publication Date
Nov 14, 2017
Volume
89
Issue
20
Pages
2039–2048
Identifiers
DOI: 10.1212/WNL.0000000000004652
PMID: 29030451
Source
Medline
License
Unknown

Abstract

These prevalence estimates are important for understanding age-related trends in amyloid positivity and AD signature cortical thickness in the population, and for potentially projecting the future burden of biomarkers in elderly persons.

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