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Weight-reducing effect of Acer truncatum Bunge may be related to the inhibition of fatty acid synthase.

Authors
  • Zhao, Wen-Hua
  • Gao, Li-Fang
  • Gao, Wen
  • Yuan, Yong-Sheng
  • Gao, Chun-Chun
  • Cao, Li-Ge
  • Hu, Zi-Zheng
  • Guo, Jian-Qiang
  • Zhang, Ying-Xia
Type
Published Article
Journal
Natural product research
Publication Date
Feb 01, 2011
Volume
25
Issue
4
Pages
422–431
Identifiers
DOI: 10.1080/14786419.2010.488625
PMID: 21328136
Source
Medline
License
Unknown

Abstract

In order to study the anti-obesity ability and inhibition towards fatty acid synthase (FAS) of the extract, a 70% ethanol extract of Acer truncatum Bunge (AT) leaves was further extracted with ethyl acetate. FAS is a very significant lipogenic enzyme, participating in energy metabolism in vivo; it has also been observed that FAS inhibitors might be potent anti-obesity agents. Experimental results on animals showed that the extract significantly reduced food intake and adipose, and effectively controlled weight evolution. Lipogenesis inhibition might be regarded as one of the reasons for the weight control and adipose reduction by AT. The extract was further isolated using a series of column chromatography that yielded 10 known compounds. 1,2,3,4,6-Penta-O-galloyl-β-D-glucose was found to be one of the major active constituents in the extract of AT.

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