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Weight loss in Huntington disease increases with higher CAG repeat number.

Authors
  • Aziz, N A
  • van der Burg, J M M
  • Landwehrmeyer, G B
  • Brundin, P
  • Stijnen, T
  • Roos, R A C
Type
Published Article
Journal
Neurology
Publisher
Ovid Technologies (Wolters Kluwer) - American Academy of Neurology
Publication Date
Nov 04, 2008
Volume
71
Issue
19
Pages
1506–1513
Identifiers
DOI: 10.1212/01.wnl.0000334276.09729.0e
PMID: 18981372
Source
Medline
License
Unknown

Abstract

Weight loss in Huntington disease (HD) is directly linked to CAG repeat length and is likely to result from a hypermetabolic state. Other signs and symptoms of HD are unlikely to contribute to weight loss in early disease stages. Elucidation of the responsible mechanisms could lead to effective energy-based therapeutics.

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