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Wee1-dependent mechanisms required for coordination of cell growth and cell division.

Authors
Type
Published Article
Journal
Journal of Cell Science
Publisher
The Company of Biologists
Volume
116
Issue
Pt 24
Pages
4883–4890
Source
UCSC Cancer biomedical-ucsc
License
Unknown

Abstract

Wee1-related kinases function in a highly conserved mechanism that controls the timing of entry into mitosis. Loss of Wee1 function causes fission yeast and budding yeast cells to enter mitosis before sufficient growth has occurred, leading to formation of daughter cells that are smaller than normal. Early work in fission yeast suggested that Wee1 is part of a cell-size checkpoint that prevents entry into mitosis before cells have reached a critical size. Recent experiments in fission yeast and budding yeast have provided new support for this idea. In addition, studies in budding yeast have revealed the existence of highly intricate signaling networks that are required for regulation of Swe1, the budding yeast homolog of Wee1. Further understanding of these signaling networks may provide important clues to how cell growth and cell division are coordinated.

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