Affordable Access

Access to the full text

A web-based intervention to promote physical activity in adolescents and young adults with cystic fibrosis: protocol for a randomized controlled trial

  • Cox, Narelle S.1
  • Eldridge, Beverley2
  • Rawlings, Sarah3
  • Dreger, Julianna4
  • Corda, Jennifer5
  • Hauser, Jennifer6
  • Button, Brenda M.7
  • Bishop, Jennifer8
  • Nichols, Amanda9
  • Middleton, Anna10
  • Ward, Nathan11
  • Dwyer, Tiffany12
  • Tomlinson, Owen W.13
  • Denford, Sarah13
  • Barker, Alan R.13
  • Williams, Craig A.13
  • Kingsley, Michael14
  • O’Halloran, Paul15
  • Holland, Anne E.16
  • 1 Monash University, La Trobe University and Institute for Breathing and Sleep, Level 6, The Alfred Centre, 99 Commercial Road, Melbourne, Vic, 3004, Australia , Melbourne (Australia)
  • 2 La Trobe University, Level 4, The Alfred Centre, 99 Commercial Road, Melbourne, Vic, 3004, Australia , Melbourne (Australia)
  • 3 Monash Children’s Hospital Monash University and La Trobe University, 246 Clayton Rd, Clayton, Vic, 3168, Australia , Clayton (Australia)
  • 4 Monash University, La Trobe University and Alfred Health, Level 6, The Alfred Centre, 99 Commercial Road, Melbourne, Vic 3004, Australia , Melbourne (Australia)
  • 5 Physiotherapy Department Royal Children’s Hospital, 50 Flemington Road Parkville, Victoria, 3052, Australia , Victoria (Australia)
  • 6 Royal Hobart Hospital, GPO Box 1061, Hobart, Tasmania, 7000, Australia , Hobart (Australia)
  • 7 Monash University, 55 Commercial Road, Melbourne, Vic, 3004, Australia , Melbourne (Australia)
  • 8 Westmead Hospital, Wentworthville, NSW, 2145, Australia , Wentworthville (Australia)
  • 9 Monash Children’s Hospital/Monash Health CF Service, 246 Clayton Rd, Clayton, Victoria, 3168, Australia , Clayton (Australia)
  • 10 Children’s Hospital at Westmead, Hawkesbury Road, Westmead, NSW, 2145, Australia , Westmead (Australia)
  • 11 Physiotherapy and Cystic Fibrosis Services, 8E055.08, Royal Adelaide Hospital, Port Road, Adelaide, SA, 5000, Australia , Adelaide (Australia)
  • 12 The University of Sydney, PO Box 170, Lidcombe, NSW, 1825, Australia , Lidcombe (Australia)
  • 13 St. Luke’s Campus, University of Exeter, Heavitree Road, Exeter, Devon, EX1 2LU, UK , Exeter (United Kingdom)
  • 14 La Trobe University, Bendigo, Vic, 3552, Australia , Bendigo (Australia)
  • 15 La Trobe University, Bundoora, Vic, 3086, Australia , Bundoora (Australia)
  • 16 Monash University La Trobe University, Alfred Health and Institute for Breathing and Sleep, Level 6, The Alfred Centre, 99 Commercial Road, Melbourne, Vic, 3004, Australia , Melbourne (Australia)
Published Article
BMC pulmonary medicine
Publication Date
Dec 19, 2019
DOI: 10.1186/s12890-019-0942-3
Springer Nature


BackgroundRegular participation in physical activity by people with cystic fibrosis (CF) promotes positive clinical and health outcomes including reduced rate of decline in lung function, fewer hospitalizations and greater wellbeing. However adherence to exercise and activity programs is low, in part due to the substantial daily therapy burden for young people with CF. Strict infection control requirements limit the role of group exercise programs that are commonly used in other clinical groups. Investigation of methods to promote physical activity in this group has been limited. The Active Online Physical Activity in Cystic fibrosis Trial (ActionPACT) is an assessor-blinded, multi-centre, randomized controlled trial designed to compare the efficacy of a novel web-based program (ActivOnline) compared to usual care in promoting physical activity participation in adolescents and young adults with CF.MethodsAdolescents and young adults with CF will be recruited on discharge from hospital for a respiratory exacerbation. Participants randomized to the intervention group will have access to a web-based physical activity platform for the 12-week intervention period. ActivOnline allows users to track their physical activity, set goals, and self-monitor progress. All participants in both groups will be provided with standardised information regarding general physical activity recommendations for adolescents and young adults.Outcomes will be assessed by a blinded assessor at baseline, after completion of the intervention, and at 3-months followup. Healthcare utilization will be assessed at 12 months from intervention completion. The primary outcome is change in moderate-to-vigorous physical activity participation measured objectively by accelerometry. Secondary outcomes include aerobic fitness, health-related quality of life, anxiety and depression and sleep quality.DiscussionThis trial will establish whether a web-based application can improve physical activity participation more effectively than usual care in the period following hospitalization for a respiratory exacerbation. The web-based application under investigation can be made readily and widely available to all individuals with CF, to support physical activity and exercise participation at a time and location of the user’s choosing, regardless of microbiological status.Trial registrationClinical trial registered on July 13, 2017 with the Australian and New Zealand Clinical Trials Register at (ACTRN12617001009303).

Report this publication


Seen <100 times