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Weapons in disguise--activating mechanisms and protecting group chemistry in nature.

Authors
  • Kwan, Jason C
  • Luesch, Hendrik
Type
Published Article
Journal
Chemistry - A European Journal
Publisher
Wiley (John Wiley & Sons)
Publication Date
Nov 22, 2010
Volume
16
Issue
44
Pages
13020–13029
Identifiers
DOI: 10.1002/chem.201001562
PMID: 20931575
Source
Medline
License
Unknown

Abstract

Bioactive natural products often possess uniquely functionalized structures with unusual modes of action; however, the natural product itself is not always the active species. We discuss molecules that draw on protecting group chemistry or else require activation to unmask reactive centers, illustrating that nature is not only a source of complex structures but also a guide for elegant chemical transformations which provides ingenious chemical solutions for drug delivery.

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