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Are we getting closer to valid translational models for major depression?

Authors
  • Berton, Olivier
  • Hahn, Chang-Gyu
  • Thase, Michael E
Type
Published Article
Journal
Science
Publisher
American Association for the Advancement of Science (AAAS)
Publication Date
Oct 05, 2012
Volume
338
Issue
6103
Pages
75–79
Identifiers
DOI: 10.1126/science.1222940
PMID: 23042886
Source
Medline
License
Unknown

Abstract

Advances in characterizing the neuropathology and functional dysconnectivity of depression and promising trials with emerging circuit-targeted and fast-onset therapeutics are providing unprecedented opportunities to gain deeper insight into the neurobiology of this devastating and pervasive disorder. Because of practical and ethical limitations to dissecting these mechanisms in humans, continued progress will critically depend on our ability to emulate aspects of depressive symptomatology and treatment response in nonhuman organisms. Although various experimental models are currently available, they often draw skepticism from both clinicians and basic research scientists. We review recent progress and highlight some of the best leads to diversify and improve discovery end points for preclinical depression research.

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