Affordable Access

Access to the full text

On the way to understand biological complexity in plants: S-nutrition as a case study for systems biology

Authors
  • Hesse, Holger
  • Hoefgen, Rainer
Type
Published Article
Journal
Cellular & Molecular Biology Letters
Publisher
Springer (Biomed Central Ltd.)
Publication Date
Mar 01, 2006
Volume
11
Issue
1
Pages
37–56
Identifiers
DOI: 10.2478/s11658-006-0004-8
Source
De Gruyter
Keywords
License
Green

Abstract

The establishment of technologies for high-throughput DNA sequencing (genomics), gene expression (transcriptomics), metabolite and ion analysis (metabolomics/ionomics) and protein analysis (proteomics) carries with it the challenge of processing and interpreting the accumulating data sets. Publicly accessible databases and newly development and adapted bioinformatic tools are employed to mine this data in order to filter relevant correlations and create models describing physiological states. These data allow the reconstruction of networks of interactions of the various cellular components as enzyme activities and complexes, gene expression, metabolite pools or pathway flux modes. Especially when merging information from transcriptomics, metabolomics and proteomics into consistent models, it will be possible to describe and predict the behaviour of biological systems, for example with respect to endogenous or environmental changes. However, to capture the interactions of network elements requires measurements under a variety of conditions to generate or refine existing models. The ultimate goal of systems biology is to understand the molecular principles governing plant responses and consistently explain plant physiology.

Report this publication

Statistics

Seen <100 times