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No way out: when RNA elements promote nuclear retention

Authors
  • Agostini, Federico1
  • Ule, Jernej1, 2
  • Zagalak, Julian A1, 2
  • 1 The Francis Crick Institute, UK , (United Kingdom)
  • 2 UCL Institute of Neurology, UK , (United Kingdom)
Type
Published Article
Journal
The EMBO Journal
Publisher
EMBO
Publication Date
Feb 27, 2018
Volume
37
Issue
6
Identifiers
DOI: 10.15252/embj.201899123
PMID: 29487065
PMCID: PMC5852650
Source
PubMed Central
Keywords
License
Unknown
External links

Abstract

The proper localization of RNA transcripts is a highly controlled and fine‐tuned process. Indeed, regulation of RNA trafficking is mediated by both cis ‐acting elements and trans ‐acting factors, and defects in either mechanism have been associated with disease. Identifying the RNA sequence motifs that determine cellular localization for a given transcript therefore represents an important and challenging task. A new study from Shukla et al in The EMBO Journal —along with related work from Lubelsky and Ulitsky published elsewhere—describes a new screen that uses hybrid RNA s with barcoded oligonucleotides to identify cis ‐acting elements that increase the propensity of RNA s to be retained in the nuclear compartment.

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