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Waxholm Space atlas of the rat brain auditory system: Three-dimensional delineations based on structural and diffusion tensor magnetic resonance imaging.

Authors
  • Osen, Kirsten K1
  • Imad, Jala1
  • Wennberg, Arvind E1
  • Papp, Eszter A1
  • Leergaard, Trygve B2
  • 1 Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo, Norway. , (Norway)
  • 2 Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo, Norway. Electronic address: [email protected] , (Norway)
Type
Published Article
Journal
NeuroImage
Publisher
Elsevier
Publication Date
May 14, 2019
Volume
199
Pages
38–56
Identifiers
DOI: 10.1016/j.neuroimage.2019.05.016
PMID: 31100433
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

The mammalian auditory system comprises a complex network of brain regions. Interpretations and comparisons of experimental results from this system depend on appropriate anatomical identification of auditory structures. The Waxholm Space (WHS) atlas of the Sprague Dawley rat brain (Papp et al., Neuroimage 97:374-86, 2014) is an open access, three-dimensional reference atlas defined in an ex-vivo magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI) volume. Version 2.0 of the atlas (Kjonigsen et al., Neuroimage 108:441-9, 2015) includes detailed delineations of the hippocampus and several major subcortical regions, but only few auditory structures. To amend this, we have delineated the complete ascending auditory system from the cochlea to the cerebral cortex. 40 new brain structure delineations have been added, and the delineations of 10 regions have been revised based on the interpretation of image features in the WHS rat brain MRI/DTI volumes. We here describe and validate the new delineations in relation to corresponding cell- and myelin-stained histological sections and previous literature. We found it possible to delineate all main regions and the majority of subregions and fibre tracts of the ascending auditory pathway, apart from the auditory cortex, for which delineations were extrapolated from a conventional two-dimensional atlas. By contrast, only parts of the descending pathways were discernible in the template. Version 3.0 of the atlas, with altogether 118 anatomical delineations, is shared via the NeuroImaging Tools and Resources Collaboratory (www.nitrc.org). Copyright © 2019 The Authors. Published by Elsevier Inc. All rights reserved.

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