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Water-soluble amphotericin B-polyvinylpyrrolidone complexes with maintained antifungal activity against Candida spp. and Aspergillus spp. and reduced haemolytic and cytotoxic effects.

Authors
  • Charvalos, Ekatherina
  • Tzatzarakis, Manolis N
  • Van Bambeke, Françoise
  • Tulkens, Paul M
  • Tsatsakis, Aristidis M
  • Tzanakakis, George N
  • Mingeot-Leclercq, Marie-Paule
Type
Published Article
Journal
The Journal of antimicrobial chemotherapy
Publication Date
Feb 01, 2006
Volume
57
Issue
2
Pages
236–244
Identifiers
PMID: 16361329
Source
Medline
License
Unknown

Abstract

AmB-PVP complexes compared favourably with AmB for antifungal activity, were less haemolytic and cytotoxic than AmB, and show a similar cytotoxicity profile to AmBisome.

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