Affordable Access

Publisher Website

Wastewater-based surveillance in Italy leading to the first detection of mcr-10-positive Klebsiella quasipneumoniae.

Authors
  • Formenti, Nicoletta1
  • Guarneri, Flavia1
  • Bertasio, Cristina1
  • Parisio, Giovanni1
  • Romeo, Claudia2
  • Scali, Federico1
  • Birbes, Laura1
  • Boniotti, Maria Beatrice1
  • Diegoli, Giuseppe3
  • Candela, Loredana4
  • Romeo, Gianluca Antonio4, 5
  • Pasquali, Paolo6
  • Alborali, Giovanni Loris1
  • 1 Istituto Zooprofilattico Sperimentale Della Lombardia e dell'Emilia Romagna "Bruno Ubertini", Brescia, Italy. , (Italy)
  • 2 Istituto Zooprofilattico Sperimentale Della Lombardia e dell'Emilia Romagna "Bruno Ubertini", Brescia, Italy. [email protected]. , (Italy)
  • 3 Regione Emilia Romagna - Settore Prevenzione Collettiva e Sanità Pubblica, Bologna, Italy. , (Italy)
  • 4 Ministero della Salute - Direzione Generale della Sanità Animale e dei Farmaci Veterinari, Rome, Italy. , (Italy)
  • 5 Istituto Zooprofilattico Sperimentale dell'Abruzzo e del Molise "G. Caporale", Teramo, Italy. , (Italy)
  • 6 Istituto Superiore di Sanità - Dipartimento di Sicurezza Alimentare, Nutrizione e Sanità Pubblica Veterinaria, Rome, Italy. , (Italy)
Type
Published Article
Journal
Antimicrobial Resistance & Infection Control
Publisher
BioMed Central
Publication Date
Dec 09, 2022
Volume
11
Issue
1
Pages
155–155
Identifiers
DOI: 10.1186/s13756-022-01194-9
PMID: 36494741
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Wastewater-based surveillance enabled the first detection of the mobile colistin resistance gene mcr-10 in Italy. This plasmid-borne resistance gene was found in strains of Klebsiella quasipneumoniae isolated from samples of human raw sewage collected over several months. Although the isolates were phenotypically susceptible to colistin, the emergence of mcr-10 is concerning due to the highly variable expression of the gene and the potential for horizontal transfer to other species. In addition, the strains also carried an extended-spectrum β-lactamase gene and were phenotypically resistant to several beta-lactams. This study highlights the value of wastewater-based surveillance as an effective tool to monitor the emergence of antimicrobial resistance in strains circulating in the community and the environment. © 2022. The Author(s).

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. This record was last updated on 12/19/2022 and may not reflect the most current and accurate biomedical/scientific data available from NLM. The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/36494741
Report this publication

Statistics

Seen <100 times