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WASP and WIP regulate podosomes in migrating leukocytes.

Authors
Type
Published Article
Journal
Journal of microscopy
Publication Date
Volume
231
Issue
3
Pages
494–505
Identifiers
DOI: 10.1111/j.1365-2818.2008.02062.x
PMID: 18755005
Source
Medline

Abstract

Podosomes are specialized adhesion sites found in rapidly migrating and invasive cells, most notably in cells from the myeloid lineage that participate in immune surveillance and phagocyte defence mechanisms. In this review, we describe the nature of leukocyte podosomes and the regulation of their turnover during migration by the key regulatory molecules Wiskott-Aldrich syndrome protein and WASP-interacting protein.

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