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Volumetric brain changes in females with fragile X-associated tremor/ataxia syndrome (FXTAS).

Authors
  • Adams, J S
  • Adams, P E
  • Nguyen, D
  • Brunberg, J A
  • Tassone, F
  • Zhang, W
  • Koldewyn, K
  • Rivera, S M
  • Grigsby, J
  • Zhang, L
  • DeCarli, C
  • Hagerman, P J
  • Hagerman, R J
Type
Published Article
Journal
Neurology
Publisher
Ovid Technologies (Wolters Kluwer) - American Academy of Neurology
Publication Date
Aug 28, 2007
Volume
69
Issue
9
Pages
851–859
Identifiers
PMID: 17724287
Source
Medline
License
Unknown

Abstract

Females affected by fragile X-associated tremor/ataxia syndrome (FXTAS) demonstrated milder brain changes than affected males, although they showed a similar pattern of radiologic findings consistent with brain atrophy and white matter disease. FXTAS should be considered (by ordering fragile X DNA testing) in females who present with late-onset ataxia, action tremor, or neuropathy, particularly in those with a family history of mental retardation, autism, or premature ovarian failure.

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