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Voltametric Determination of Zoledronic Acid in a Pharmaceutical Formulation

Authors
  • AMRO, Abdulaziz1
  • RATROUT, Samer2
  • ASFOUR, Fadi2
  • 1 Al-Ahliyya Amman University Faculty of Pharmacy, Department of Pharmaceutical Sciences, Amman, Jordan
  • 2 Hikma Pharmaceuticals, Amman, Jordan
Type
Published Article
Journal
Turkish Journal of Pharmaceutical Sciences
Publisher
Galenos Publishing
Publication Date
Jun 18, 2021
Volume
18
Issue
3
Pages
339–343
Identifiers
DOI: 10.4274/tjps.galenos.2020.97455
PMID: 34157824
PMCID: PMC8231328
Source
PubMed Central
Keywords
Disciplines
  • Original Article
License
Unknown

Abstract

Objectives: The aim of this study is to study the electroactivity of zoledronic acid (ZOL), optimize the parameters affecting voltametric analysis of ZOL, and make a comparison between voltametric methods used to assay ZOL. Materials and Methods: Three voltametric methods, cyclic voltammetry (CV), square wave voltammetry (SWV), and differential pulse voltammetry (DPV), were used to determine the concentrations of ZOL solutions (0.25-1.2 mg.mL-1). Britton-Robinson universal buffer solutions (BRB) were used as supporting electrolytes with a glassy carbon working electrode. Results: The calibration plots were linear in the range from 0.20 to 1.2 mg.mL-1 for differential DPV and CV and from 0.09 to 1.2 mg.mL-1 for SWV. DPV showed the highest correlation coefficient R2 value of 0.993 and the lowest limit of detection (LOD) of 37.2 μg.mL-1. Furthermore, DPV exhibited the highest precision with the lowest relative standard deviations (RSD) values. For a commercial product of ZOL, DPV showed the best accuracy and precision with 102.32% recovery and 2.88% RSD. Conclusion: ZOL is an electroactive compound. The pH of the BRB supporting the electrolyte is important for ZOL electroactivity. DPV is the recommended method for voltametric analysis of ZOL because of its high-performance regarding accuracy, precision, and LOD compared with other studied methods.

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