Affordable Access

The voltage-dependent anion channel: characterization, modulation, and role in mitochondrial function in cell life and death.

Authors
  • Shoshan-Barmatz, Varda
  • Gincel, Dan
Type
Published Article
Journal
Cell biochemistry and biophysics
Publication Date
Jan 01, 2003
Volume
39
Issue
3
Pages
279–292
Identifiers
PMID: 14716081
Source
Medline
License
Unknown

Abstract

Recently, it has been recognized that there is a metabolic coupling between the cytosol and mitochondria, where the outer mitochondrial membrane (OMM), the boundary between these compartments, has important functions. In this crosstalk, mitochondrial Ca2+ homeostasis and ATP production and supply play a major role. The primary transporter of ions and metabolites across the OMM is the voltage-dependent anion channel (VDAC). The interaction of VDAC with Ca2+, ATP glutamate, NADH, and different proteins was demonstrated, and these interactions may regulate OMM permeability. This review includes information on VDAC purification methods, characterization of its channel activity (selectivity, voltage-dependence, conductance), and the regulation of VDAC channel by ligands, such as Ca2+, glutamate and ATP and touches on many aspects of the physiological relevance of VDAC to Ca2+ homeostasis and mitochondria-mediated apoptosis.

Report this publication

Statistics

Seen <100 times