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In vivo three-dimensional knee kinematics in goats with unilateral anterior cruciate ligament transection.

Authors
  • Bascuñán, Ana1
  • Soula, Mariajesus1
  • Millar, Kristina K1
  • Biedrzycki, Adam1
  • Banks, Scott A2
  • Lewis, Daniel D1
  • Kim, Stanley E1
  • 1 Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, Florida.
  • 2 Department of Mechanical and Aerospace Engineering, University of Florida, Gainesville, Florida.
Type
Published Article
Journal
Journal of Orthopaedic Research®
Publisher
Wiley (John Wiley & Sons)
Publication Date
May 01, 2021
Volume
39
Issue
5
Pages
1052–1063
Identifiers
DOI: 10.1002/jor.24795
PMID: 32633844
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Although the goat is an established animal model in anterior cruciate ligament (ACL) research, in vivo kinematics associated with ACL deficiency have not been previously described in this species. Three-dimensional knee kinematics were determined before and after unilateral ACL transection in eight goats. Fluoroscopic imaging of the knees during treadmill walking and force-platform gait analysis during over-ground walking were performed prior to ACL transection, and 2 weeks, 3 months, and 6 months after ACL transection. Transient lameness of the ACL-transected limb was noted in all goats but resolved by 3 months post-ACL transection. Increased extension of 8.7° to 17.0° was noted throughout the gait cycle in both the ACL-transected and the contralateral unaffected knees by 3 months post-ACL transection, in a bilaterally symmetric pattern. Peak anterior tibial translation increased by 3 to 6 mm after ACL transection and persisted over the 6-month study period. No changes in axial rotation or abduction angle were observed after ACL transection. Unilateral ACL deficiency in goats resulted in persistent kinematic alterations, despite the resolution of lameness by 3 months post-ACL transection. © 2020 Orthopaedic Research Society. Published by Wiley Periodicals LLC.

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