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In vivo therapy with monoclonal anti-I-A antibody suppresses immune responses to acetylcholine receptor

Authors
  • Waldor, Matthew K.
  • Sriram, Subramaniam
  • McDevitt, Hugh O.
  • Steinman, Lawrence
Publication Date
May 01, 1983
Source
PubMed Central
Keywords
Language
English
License
Unknown

Abstract

A monoclonal antibody to I-A gene products of the immune response gene complex attenuates both humoral and cellular responses to acetylcholine receptor and appears to suppress clinical manifestations of experimental autoimmune myasthenia gravis. This demonstrates that use of antibodies against immune response gene products that are associated with susceptibility to disease may be feasible for therapy in autoimmune conditions such as myasthenia gravis.

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