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In vivo response of the normal and regenerating adrenal glands to thyroid manipulation in rats.

Authors
  • Udoye, M O
  • Nonavinakere, V K
  • Soliman, K F
Type
Published Article
Journal
Research communications in molecular pathology and pharmacology
Publication Date
Feb 01, 1997
Volume
95
Issue
2
Pages
221–224
Identifiers
PMID: 9090758
Source
Medline
License
Unknown

Abstract

Adrenal corticosterone (CORT) levels and ornithine decarboxylase (ODC) activities in thyroid intact, thyroidectomized, and thyroxine (2 micrograms/ml in drinking water for 3 weeks) supplemented rats were measured 11 days after adrenal sham surgery or enucleation. Thyroidectomy decreased and thyroxine supplementation increased adrenal CORT significantly (p < 0.05) at 0600 h and 1800 h. The ODC activity was not significantly affected by thyroidectomy. Thyroxine supplementation however, inhibited ODC activity significantly (p < 0.05) at 1800 h in the regenerating adrenal cortex. Results indicated that, while CORT response in normal and regenerating adrenals are positively related to thyroid manipulation, inhibition of adrenal ODC activity by thyroxine may affect adrenal regeneration.

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