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In Vivo Model Systems for Hepatitis B Virus Research

Authors
  • Ortega-Prieto, Ana Maria
  • Cherry, Catherine
  • Gunn, Harry
  • Dorner, Marcus
Type
Published Article
Journal
ACS Infectious Diseases
Publisher
American Chemical Society
Publication Date
Dec 12, 2018
Volume
5
Issue
5
Pages
688–702
Identifiers
DOI: 10.1021/acsinfecdis.8b00223
PMID: 30539633
PMCID: PMC6515358
Source
PubMed Central
Keywords
License
Unknown

Abstract

Hepatitis B virus (HBV) affects more than 257 million people globally, resulting in progressively worsening liver disease, manifesting as fibrosis, cirrhosis, and hepatocellular carcinoma. The exceptionally narrow species tropism of HBV restricts its natural hosts to humans and non-human primates, including chimpanzees, gorillas, gibbons, and orangutans. The unavailability of completely immunocompetent small-animal models has contributed to the lack of curative therapeutic interventions. Even though surrogates allow the study of closely related viruses, their host genetic backgrounds, immune responses, and molecular virology differ from those of HBV. Various different models, based on either pure murine or xenotransplantation systems, have been introduced over the past years, often making the choice of the optimal model for any given question challenging. Here, we offer a concise review of in vivo model systems employed to study HBV infection and steps in the HBV life cycle or pathogenesis.

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