In vivo kinetic analysis of covalent binding between N-acetyl-L-cysteine and plasma protein through the formation of mixed disulfide in rats.
- Published Article
- Publication Date
May 01, 2002
We demonstrated that plasma total drug clearance is kinetically limited by covalent protein binding. The compartmental model described here is useful for analyzing its kinetics in vivo.
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The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/12069163