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In vivo kinetic analysis of covalent binding between N-acetyl-L-cysteine and plasma protein through the formation of mixed disulfide in rats.

Authors
  • Harada, Daisuke
  • Naito, Shinsaku
  • Hiraoka, Isao
  • Otagiri, Masaki
Type
Published Article
Journal
Pharmaceutical research
Publication Date
May 01, 2002
Volume
19
Issue
5
Pages
615–620
Identifiers
PMID: 12069163
Source
Medline
License
Unknown

Abstract

We demonstrated that plasma total drug clearance is kinetically limited by covalent protein binding. The compartmental model described here is useful for analyzing its kinetics in vivo.

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