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In vivo expression of cytokine receptor mRNA in atopic dermatitis.

Authors
  • Taha, R A
  • Leung, D Y
  • Ghaffar, O
  • Boguniewicz, M
  • Hamid, Q
Type
Published Article
Journal
Journal of Allergy and Clinical Immunology
Publisher
Elsevier
Publication Date
Aug 01, 1998
Volume
102
Issue
2
Pages
245–250
Identifiers
PMID: 9723668
Source
Medline
License
Unknown

Abstract

These results demonstrate that acute AD is associated with a high expression of IL-4Ralpha, whereas IL-5Ralpha and GM-CSFRalpha mRNA are predominantly increased in chronic AD and to lesser extent in acute lesions. These findings support the biphasic role of IL-4, IL-5, and GM-CSF in the pathophysiology of AD.

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