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[In vivo effects of anti-cam antibody on OA sensitized rats].

Authors
Type
Published Article
Journal
Arerugī = [Allergy]
Publication Date
Volume
43
Issue
4
Pages
579–584
Identifiers
PMID: 7913316
Source
Medline
License
Unknown

Abstract

To determine the role of cell adhesion molecules, we evaluated the in vivo effects of anti-intercellular adhesion molecule-1 (ICAM-1) monoclonal antibody (1A29) and anti-leukocyte function associated molecule-1 (LFA-1) monoclonal antibody (WT-1) on ovalbumin (OA) sensitized rats. Both sneezing discharges and nasal rubbing movements after nasal OA challenge were significantly inhibited by these monoclonal antibody administrations (control vs treated group; 20.5 +/- 5.0 vs 7.0 +/- 2.9 times/minutes, p < 0.01 and and 56.8 +/- 7.1 vs 26.9 +/- 2.9 times/15 minutes, p < 0.01, for sneezing and rubbing, respectively). The number of eosinophils in nasal mucosa 24 hours after the challenge was also inhibited by the treatment (control vs treatment group; 108.8 +/- 27.3 vs 13.8 +/- 6.9 p < 0.01). These results suggest some pathophysiological roles of ICAM-1 and LFA-1 in nasal allergy.

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