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In vivo comparison of bioactive glass particles in rabbits.

Authors
Type
Published Article
Journal
Biomaterials
0142-9612
Publisher
Elsevier
Publication Date
Volume
22
Issue
4
Pages
357–362
Identifiers
PMID: 11205439
Source
Medline
License
Unknown

Abstract

Bioglass particles of the compositions 45s5, 52s and 55s were implanted in the distal femoral epiphysis of rabbits. Animals were sacrificed at 7, 28, and 84 d postoperatively and specimens investigated using light microscopy and histomorphometry. Bone bonding occurred in a zentripetal fashion and fastest for 45s5. Bone formation was hampered at the core of the implantation bed where bone bonding showed a peak at 28d and diminished at 84d (except for 55s). This went along with a significant increase in numerous multinuclear giant cells (MNGC). Implantation model, particle size and surface-area-to-volume ratio are discussed as possible parameters determining bone regeneration.

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