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In vivo assimilation of low density lipoproteins by a fibrosarcoma tumour line in mice.

Authors
  • Norata, G
  • Canti, G
  • Ricci, L
  • Nicolin, A
  • Trezzi, E
  • Catapano, A L
Type
Published Article
Journal
Cancer Letters
Publisher
Elsevier
Publication Date
Dec 01, 1984
Volume
25
Issue
2
Pages
203–208
Identifiers
PMID: 6095991
Source
Medline
License
Unknown

Abstract

A tumour line inoculated in mice showed high affinity binding for lipoproteins in vitro. Studies in vivo demonstrated that the assimilation of human low density lipoprotein (LDL) by the tumour was very high. Both receptor and non-receptor mediated catabolism of the lipoprotein by the tumour increased as compared to other tissues known to be sites of lipoprotein catabolism (liver, spleen etc.). These findings suggest that lipoproteins may be useful markers for tumours as well as carriers for cytotoxic drugs to target tissues in vivo.

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