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In vivo assessment of anticoagulant and antiplatelet effects of Syzygium cumini leaves extract in rabbits

Authors
  • Rehman, Ahad Abdul1
  • Riaz, Azra2
  • Asghar, Muhammad Arif3
  • Raza, Muhammad Liaquat4
  • Ahmed, Shadab2
  • Khan, Kamran3
  • 1 Jinnah Sindh Medical University, Department of Pharmacology, Faculty of Pharmacy, Rafiqui H.J Shaheed Road, Karachi, 75510, Pakistan , Karachi (Pakistan)
  • 2 University of Karachi, Department of Pharmacology, Faculty of Pharmacy, Karachi, Pakistan , Karachi (Pakistan)
  • 3 Jinnah Sindh Medical University, Department of Pharmaceutics, Faculty of Pharmacy, Rafiqui H.J Shaheed Road, Karachi, 75510, Pakistan , Karachi (Pakistan)
  • 4 Lund University Hospital, Department of Clinical Sciences, Faculty of Medicine, Lund, Sweden , Lund (Sweden)
Type
Published Article
Journal
BMC Complementary and Alternative Medicine
Publisher
Springer (Biomed Central Ltd.)
Publication Date
Sep 03, 2019
Volume
19
Issue
1
Identifiers
DOI: 10.1186/s12906-019-2661-y
Source
Springer Nature
Keywords
License
Green

Abstract

BackgroundSyzygium cumini (L.) Skeels. is one of the very popular traditionally used medicinal plants with numerous pharmacological activities including antioxidant, hypoglycemic and anti-inflammatory. However, actions of S. cumini on blood coagulation and other parameters of blood were poorly pharmacologically studied. Therefore, aim of this present investigation is to examine the effects of methanolic extract of S. cumini on blood coagulation and anticoagulation factors in healthy white albino rabbits at different doses.MethodsBlood samples were drawn twice during this study and biochemical assays were performed to determine the effect on different parameters such as coagulation, anticoagulation, hematological, Protein C (PC) and thrombin antithrombin (TAT) complex and platelet aggregation.ResultsThe results showed significant increase in RBCs, hemoglobin, hematocrit and platelets counts up to 1.4 × 103/cm, 2.2 g/dl, 6%, 248.2 × 103/cm respectively. While, thrombin and bleeding time were also prolonged in dose dependent manner which is highly significant (p ≤ 0.005) as compared to control. Similarly, highly significantly increased (p ≤ 0.005) in levels of protein C, thrombin antithrombin complex at dose of 500 mg/kg were observed. Whereas, levels of platelets aggregation and fibrinogen were decreased at high doses.ConclusionThe obtained findings of hematological and coagulation tests concludes possibly S. cumini possess anticoagulant and antiplatelet effects.

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