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In vivo antimalarial efficacy of acetogenins, alkaloids and flavonoids enriched fractions from Annona crassiflora Mart.

Authors
  • Pimenta, Lúcia Pinheiro Santos
  • Garcia, Giani Martins
  • Gonçalves, Samuel Geraldo do Vale
  • Dionísio, Bárbara Lana
  • Braga, Erika Martins
  • Mosqueira, Vanessa Carla Furtado
Type
Published Article
Journal
Natural product research
Publication Date
Jan 01, 2014
Volume
28
Issue
16
Pages
1254–1259
Identifiers
DOI: 10.1080/14786419.2014.900496
PMID: 24678811
Source
Medline
Keywords
License
Unknown

Abstract

Annona crassiflora and Annonaceae plants are known to be used to treat malaria by traditional healers. In this work, the antimalarial efficacy of different fractions of A. crassiflora, particularly acetogenin, alkaloids and flavonoid-rich fractions, was determined in vivo using Plasmodium berghei-infected mice model and toxicity was accessed by brine shrimp assay. The A. crassiflora fractions were administered at doses of 12.5 mg/kg/day in a 4-day test protocol. The results showed that some fractions from woods were rich in acetogenins, alkaloids and terpenes, and other fractions from leaves were rich in alkaloids and flavonoids. The parasitaemia was significantly (p < 0.05, p < 0.001) reduced (57-75%) with flavonoid and alkaloid-rich leaf fractions, which also increased mean survival time of mice after treatment. Our results confirm the usage of this plant in folk medicine as an antimalarial remedy.

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