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In vivo administration of nimesulide, a selective PGHS-2 inhibitor, increases in vitro myometrial sensitivity to prostaglandins while lowering sensitivity to oxytocin.

Authors
  • Baguma-Nibasheka, M
  • Nathanielsz, P W
Type
Published Article
Journal
Journal of the Society for Gynecologic Investigation
Publication Date
Jan 01, 1998
Volume
5
Issue
6
Pages
296–299
Identifiers
PMID: 9824808
Source
Medline
License
Unknown

Abstract

The results show that nimesulide lowers spontaneous myometrial contractility and sensitivity to oxytocin while increasing sensitivity to PGs, indicating a down-regulation of oxytocin receptor and an up-regulation of PG receptors and/or intracellular signaling events.

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