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In vivo 1H chemical shift imaging of silicone implants.

Authors
  • Pfleiderer, B
  • Ackerman, J L
  • Garrido, L
Type
Published Article
Journal
Magnetic resonance in medicine
Publication Date
May 01, 1993
Volume
29
Issue
5
Pages
656–659
Identifiers
PMID: 8505902
Source
Medline
License
Unknown

Abstract

In order to study the aging process (i.e., silicone migration, fat infiltration) of silicone (polydimethylsiloxane, PDMS) based biomaterials in living subjects by NMR imaging, a hybrid 1H selective excitation and saturation chemical shift imaging technique (IR/CHESS-CSSE) has been developed. This sequence allows selective mapping of the distribution of silicone protons in vivo, while suppressing the contributions of fat and water. Our results indicate that a combined inversion recovery and CHESS pulse, followed by a spoiler gradient, must be applied to suppress all contributions of fat protons to the NMR signal. The sensitivity of our experiments allows the detection of a chemically unchanged silicone concentration of 5% in a voxel of 0.9 mm3 at a signal/noise ratio of 2.

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