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In vitro and in vivo assessment of linezolid combined with ertapenem: a highly synergistic combination against methicillin-resistant Staphylococcus aureus.

Authors
  • Jacqueline, Cedric
  • Caillon, Jocelyne
  • Grossi, Olivier
  • Le Mabecque, Virginie
  • Miegeville, Anne-Françoise
  • Bugnon, Denis
  • Batard, Eric
  • Potel, Gilles
Type
Published Article
Journal
Antimicrobial agents and chemotherapy
Publication Date
Jul 01, 2006
Volume
50
Issue
7
Pages
2547–2549
Identifiers
PMID: 16801442
Source
Medline
License
Unknown

Abstract

Linezolid in combination with ertapenem showed in vitro synergy against methicillin-resistant Staphylococcus aureus strains. We confirmed this interaction in vivo by using a rabbit endocarditis experimental model and simulation of the human pharmacokinetics in animals for both antibiotics. Linezolid plus ertapenem exhibited highly synergistic activity in vivo after 4 days of treatment.

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